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Saxenda vs Retatrutide: Titration Speed and Tolerability Compared At a glance Drug class (Saxenda) / GLP-1 receptor agonist, daily subcutaneous injection Drug class (Retatrutide) / GIP + GLP-1 + glucagon triple agonist, weekly subcutaneous injection Saxenda maintenance dose / 3.0 mg daily (fixed) Retatrutide Phase 2 top dose / 12 mg weekly (weight-adaptive titration) Saxenda titration duration / 5 weeks (0.6 mg up to 3.0 mg) Retatrutide titration duration / approximately 24 weeks across multiple escalation steps Mean weight loss at trial end (Saxenda) / 8.0% at 56 weeks in SCALE (N=3,731) Mean weight loss at trial end (Retatrutide) / up to 24.2% at 48 weeks in Phase 2 (N=338) Saxenda GI discontinuation rate / approximately 9.8% in SCALE Retatrutide regulatory status / Phase 3 trials ongoing

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Ultimately, it's all about what's comfortable and what works for you.As regards the starting dose, the trial participants I spoke to generally began with 2mg, but one person told me they started with 1mg and were shifted to 4mg continuously shortly after

10.1371/journal.pone.0181880 12 BnemannM.GerhardsteinB